Role of Substitutions in the Hemagglutinin in the Emergence of the 1968 Pandemic Influenza Virus
Identifieur interne : 000524 ( Main/Exploration ); précédent : 000523; suivant : 000525Role of Substitutions in the Hemagglutinin in the Emergence of the 1968 Pandemic Influenza Virus
Auteurs : Sjouke Van Poucke [Belgique] ; Jennifer Doedt [Allemagne] ; Jan Baumann [Allemagne] ; Yu Qiu [Belgique] ; Tatyana Matrosovich [Allemagne] ; Hans-Dieter Klenk [Allemagne] ; Kristien Van Reeth [Belgique] ; Mikhail Matrosovich [Allemagne]Source :
- Journal of Virology [ 0022-538X ] ; 2015.
Abstract
Hemagglutinin (HA) of H3N2/1968 pandemic influenza viruses differs from the putative avian precursor by seven amino acid substitutions. Substitutions Q226L and G228S are known to be essential for adaptation of avian HA to mammals. We found that introduction of avian-virus-like amino acids at five other HA positions (positions 62, 81, 92, 144, and 193) of A/Hong Kong/1/1968 virus decreased viral replication in human cells and transmission in pigs. Thus, substitutions at some of these positions facilitated emergence of the pandemic virus.
Url:
DOI: 10.1128/JVI.01292-15
PubMed: 26378170
PubMed Central: 4645308
Affiliations:
- Allemagne, Belgique
- District de Giessen, Hesse (Land), Province de Flandre-Orientale, Région flamande
- Gand, Marbourg
- Université de Gand
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Le document en format XML
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flamande</region><region type="district" nuts="2">Province de Flandre-Orientale</region></placeName></affiliation></author><author><name sortKey="Matrosovich, Tatyana" sort="Matrosovich, Tatyana" uniqKey="Matrosovich T" first="Tatyana" last="Matrosovich">Tatyana Matrosovich</name><affiliation wicri:level="3"><nlm:aff id="aff2">Institute of Virology, Philipps University, Marburg, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute of Virology, Philipps University, Marburg</wicri:regionArea><placeName><region type="land" nuts="1">Hesse (Land)</region><region type="district" nuts="2">District de Giessen</region><settlement type="city">Marbourg</settlement></placeName></affiliation></author><author><name sortKey="Klenk, Hans Dieter" sort="Klenk, Hans Dieter" uniqKey="Klenk H" first="Hans-Dieter" last="Klenk">Hans-Dieter Klenk</name><affiliation wicri:level="3"><nlm:aff id="aff2">Institute of Virology, Philipps University, Marburg, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute of Virology, Philipps University, Marburg</wicri:regionArea><placeName><region type="land" nuts="1">Hesse (Land)</region><region type="district" nuts="2">District de Giessen</region><settlement type="city">Marbourg</settlement></placeName></affiliation></author><author><name sortKey="Van Reeth, Kristien" sort="Van Reeth, Kristien" uniqKey="Van Reeth K" first="Kristien" last="Van Reeth">Kristien Van Reeth</name><affiliation wicri:level="4"><nlm:aff id="aff1">Laboratory of Virology, Faculty of Veterinary Medicine, Ghent University, Merelbeke, Belgium</nlm:aff><country xml:lang="fr">Belgique</country><wicri:regionArea>Laboratory of Virology, Faculty of Veterinary Medicine, Ghent University, Merelbeke</wicri:regionArea><orgName type="university">Université de Gand</orgName><placeName><settlement type="city">Gand</settlement><region>Région flamande</region><region type="district" nuts="2">Province de Flandre-Orientale</region></placeName></affiliation></author><author><name sortKey="Matrosovich, Mikhail" sort="Matrosovich, Mikhail" uniqKey="Matrosovich M" first="Mikhail" last="Matrosovich">Mikhail Matrosovich</name><affiliation wicri:level="3"><nlm:aff id="aff2">Institute of Virology, Philipps University, Marburg, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute of Virology, Philipps University, Marburg</wicri:regionArea><placeName><region type="land" nuts="1">Hesse (Land)</region><region type="district" nuts="2">District de Giessen</region><settlement type="city">Marbourg</settlement></placeName></affiliation></author></analytic><series><title level="j">Journal of Virology</title><idno type="ISSN">0022-538X</idno><idno type="eISSN">1098-5514</idno><imprint><date when="2015">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Hemagglutinin (HA) of H3N2/1968 pandemic influenza viruses differs from the putative avian precursor by seven amino acid substitutions. Substitutions Q226L and G228S are known to be essential for adaptation of avian HA to mammals. We found that introduction of avian-virus-like amino acids at five other HA positions (positions 62, 81, 92, 144, and 193) of A/Hong Kong/1/1968 virus decreased viral replication in human cells and transmission in pigs. Thus, substitutions at some of these positions facilitated emergence of the pandemic virus.</p></div></front></TEI><affiliations><list><country><li>Allemagne</li><li>Belgique</li></country><region><li>District de Giessen</li><li>Hesse (Land)</li><li>Province de Flandre-Orientale</li><li>Région flamande</li></region><settlement><li>Gand</li><li>Marbourg</li></settlement><orgName><li>Université de Gand</li></orgName></list><tree><country name="Belgique"><region name="Région flamande"><name sortKey="Van Poucke, Sjouke" sort="Van Poucke, Sjouke" uniqKey="Van Poucke S" first="Sjouke" last="Van Poucke">Sjouke Van Poucke</name></region><name sortKey="Qiu, Yu" sort="Qiu, Yu" uniqKey="Qiu Y" first="Yu" last="Qiu">Yu Qiu</name><name sortKey="Van Reeth, Kristien" sort="Van Reeth, Kristien" uniqKey="Van Reeth K" first="Kristien" last="Van Reeth">Kristien Van Reeth</name></country><country name="Allemagne"><region name="Hesse (Land)"><name sortKey="Doedt, Jennifer" sort="Doedt, Jennifer" uniqKey="Doedt J" first="Jennifer" last="Doedt">Jennifer Doedt</name></region><name sortKey="Baumann, Jan" sort="Baumann, Jan" uniqKey="Baumann J" first="Jan" last="Baumann">Jan Baumann</name><name sortKey="Klenk, Hans Dieter" sort="Klenk, Hans Dieter" uniqKey="Klenk H" first="Hans-Dieter" last="Klenk">Hans-Dieter Klenk</name><name sortKey="Matrosovich, Mikhail" sort="Matrosovich, Mikhail" uniqKey="Matrosovich M" first="Mikhail" last="Matrosovich">Mikhail Matrosovich</name><name sortKey="Matrosovich, Tatyana" sort="Matrosovich, Tatyana" uniqKey="Matrosovich T" first="Tatyana" last="Matrosovich">Tatyana Matrosovich</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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